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Dengue Literature - Latest PubMed Articles

Overview of latest articles and publications on ebola in PubMed. PubMed is a service of the US National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals.


  • Nanotitania crystals induced efficient photocatalytic color degradation, antimicrobial and larvicidal activity.
    Nanotitania crystals induced efficient photocatalytic color degradation, antimicrobial and larvicidal activity. [Journal Article]J Photochem Photobiol B 2017 Dec 06.:496-504.JPUdayabhanu J, Kannan V, Tiwari M, et al. Textile industries release tonnes of harmful toxic dyes into the environment, causing severe effects on living organisms, including humans. Mosquitoes vectors spread important diseases which cause mill...Publisher Full TextTextile industries release tonnes of harmful toxic dyes into the environment, causing severe effects on living organisms, including humans. Mosquitoes vectors spread important diseases which cause millions of human deaths worldwide. To control mosquitoes a number of synthetic mosquitocidal agents have been employed but all these pesticides pose harmful effects to human health and non-target species and also led to resistance development in treated vectors. Microbial strains are also developing resistance to the available antibiotics, this currently represents a major public health challenge. The current study is focused on the green synthesis of titanium dioxide nanoparticles (TiO2 NPs) using aqueous leaf extracts of Euphorbia hirta. Results suggested an efficient remedy for the above mentioned problems using TiO2 NPs against the dye degradation, mosquito larvae and bacterial pathogens. The fabrication of TiO2 NPs was confirmed by UV-visible spectroscopy, the biomolecules involved in the synthesis process were evidenced by Fourier transform infra-red spectroscopy (FT-IR), the crystalline structure was observed by using X-ray powder diffraction (XRD) analysis. Spherical shaped TiO2NPs were recorded using field emission scanning electron microscopy (FESEM). Energy dispersive X-ray spectroscopy (EDX) results showed the elemental composition of TiO2 NPs. Enhanced rate of photocatalytic dye degradation efficacy was recorded in in methylene blue (95.8%) followed by crystal violet (86.7%). Antibacterial activity assays indicated growth inhibition was highest in Staphylococcus epidermidis and Proteus vulgaris. The LC50 of TiO2 NPs and E. hirta extract on Aedes aegypti larvae were 13.2mg/l and 81.2mg/l, while on Culex quinquefasciatus they were 6.89mg/l and 46.1mg/l respectively. Overall, based on the results of the present study, the green engineered nanotitania could be considered as novel and promising photocatalytic, antibacterial, and mosquitocidal agent.

  • Balancing geo-privacy and spatial patterns in epidemiological studies.
    Balancing geo-privacy and spatial patterns in epidemiological studies. [Journal Article]Geospat Health 2017 Nov 08; 12(2):573.GHChen CC, Chuang JH, Wang DW, et al. To balance the protection of geo-privacy and the accuracy of spatial patterns, we developed a geo-spatial tool (GeoMasker) intended to mask the residential locations of patients or cases in a geographi...Publisher Full TextTo balance the protection of geo-privacy and the accuracy of spatial patterns, we developed a geo-spatial tool (GeoMasker) intended to mask the residential locations of patients or cases in a geographic information system (GIS). To elucidate the effects of geo-masking parameters, we applied 2010 dengue epidemic data from Taiwan testing the tool's performance in an empirical situation. The similarity of pre- and post-spatial patterns was measured by D statistics under a 95% confidence interval. In the empirical study, different magnitudes of anonymisation (estimated Kanonymity ≥10 and 100) were achieved and different degrees of agreement on the pre- and post-patterns were evaluated. The application is beneficial for public health workers and researchers when processing data with individuals' spatial information.

  • Analytical report of the 2016 dengue outbreak in Córdoba city, Argentina.
    Analytical report of the 2016 dengue outbreak in Córdoba city, Argentina. [Journal Article]Geospat Health 2017 Nov 06; 12(2):564.GHRotela C, Lopez L, Frías Céspedes M, et al. After elimination of the Aedes aegypti vector in South America in the 1960s, dengue outbreaks started to reoccur during the 1990s; strongly in Argentina since 1998. In 2016, Córdoba City had the larges...After elimination of the Aedes aegypti vector in South America in the 1960s, dengue outbreaks started to reoccur during the 1990s; strongly in Argentina since 1998. In 2016, Córdoba City had the largest dengue outbreak in its history. In this article we report this outbreak including spatio-temporal analysis of cases and vectors in the city. A total of 653 dengue cases were recorded by the laboratory-based dengue surveillance system and georeferenced by their residential addresses. Case maps were generated from the epidemiological week 1 (beginning of January) to week 19 (mid-May). Dengue outbreak temporal evolution was analysed globally and three specific, high-incidence zones were detected using Knox analysis to characterising its spatio-temporal attributes. Field and remotely sensed data were collected and analysed in real time and a vector presence map based on the MaxEnt approach was generated to define hotspots, towards which the pesticide- based strategy was then targeted. The recorded pattern of cases evolution within the community suggests that dengue control measures should be improved.

  • Insecticide susceptibility status of invasive Aedes albopictus across dengue endemic districts of Odisha, India.
    Insecticide susceptibility status of invasive Aedes albopictus across dengue endemic districts of Odisha, India. [Journal Article]Pest Manag Sci 2017 Dec 14.PMRath A, Mohanty I, Hazra RK This is the first report of a kdr mutation in Ae. albopictus in India and highlights the need for intensive research on other unexplored target site mutations that might also contribute to pyrethroid r...Publisher Full TextAedes albopictus is currently the most invasive mosquito species in the world. Keeping in view the wide emergence of insecticide resistance, it is imperative to focus on the current susceptibility status for various insecticides in Ae. albopictus. The present study is focused on understanding the insecticide resistance mechanism of Ae. albopictus collected from dengue endemic districts of Odisha.Insecticide resistance was evaluated by using standardized bioassay kits (WHO) and biochemical analysis. Larval bioassays revealed the highest level of resistance from JP population with RR50 of 15.3 and LC50 of 1.177ppm compared to LC50 of 0.077 for the susceptible strain LabS. Results indicated the presence of DDT resistance in the majority of adult populations. Elevated activity of non specific esterases and P450s MFO indicated probable resistance to organophosphates and pyrethroids. Molecular screening for common insecticide target-site mutations confirmed the absence of the "knock down resistance" response for pyrethroid insecticide in Ae. albopictus population suggesting its continual effectiveness as the major insecticide of significant importance in future vector control programmes.This is the first report of a kdr mutation in Ae. albopictus in India and highlights the need for intensive research on other unexplored target site mutations that might also contribute to pyrethroid resistance. Effective management and sustainable use of insecticides can be implemented by understanding resistance mechanisms and development of appropriate diagnostic tools.

  • Population genomics of the Asian tiger mosquito, Aedes albopictus: insights into the recent worldwide invasion.
    Population genomics of the Asian tiger mosquito, Aedes albopictus: insights into the recent worldwide invasion. [Journal Article]Ecol Evol 2017 Dec; 7(23):10143-10157.EEKotsakiozi P, Richardson JB, Pichler V, et al. Aedes albopictus, the "Asian tiger mosquito," is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30-40 years. The species is of great p...Aedes albopictus, the "Asian tiger mosquito," is an aggressive biting mosquito native to Asia that has colonized all continents except Antarctica during the last ~30-40 years. The species is of great public health concern as it can transmit at least 26 arboviruses, including dengue, chikungunya, and Zika viruses. In this study, using double-digest Restriction site-Associated DNA (ddRAD) sequencing, we developed a panel of ~58,000 single nucleotide polymorphisms (SNPs) based on 20 worldwide Ae. albopictus populations representing both the invasive and the native range. We used this genomic-based approach to study the genetic structure and the differentiation of Ae. albopictus populations and to understand origin(s) and dynamics of the recent invasions. Our analyses indicated the existence of two major genetically differentiated population clusters, each one including both native and invasive populations. The detection of additional genetic structure within each major cluster supports that these SNPs can detect differentiation at a global and local scale, while the similar levels of genomic diversity between native and invasive range populations support the scenario of multiple invasions or colonization by a large number of propagules. Finally, our results revealed the possible source(s) of the recent invasion in Americas, Europe, and Africa, a finding with important implications for vector-control strategies.

  • Chikungunya-dengue co-infection during pregnancy requiring preterm Caesarean section: first case report from Bangladesh.
    Chikungunya-dengue co-infection during pregnancy requiring preterm Caesarean section: first case report from Bangladesh. [Journal Article]Trop Doct 2017 Jan 01.:49475517747431.TDRahim MA, Zaman S, Sultana N, et al. We report the first case of chikungunya-dengue co-infection during pregnancy requiring emergency Caesarean section (CS) because of fetal distress in a Bangladeshi primigravida. Though previously unrepo...Publisher Full TextWe report the first case of chikungunya-dengue co-infection during pregnancy requiring emergency Caesarean section (CS) because of fetal distress in a Bangladeshi primigravida. Though previously unreported, this situation may become increasingly common.

  • Zika virus evolution on the edges of the Pacific ocean.
    Zika virus evolution on the edges of the Pacific ocean. [Journal Article]Emerg Microbes Infect 2017 Dec 13; 6(12):e111.EMDupont-Rouzeyrol M, Diancourt L, Calvez E, et al. Publisher Full Text

  • Dengue hospitalisations in Brazil: annual wave from West to East and recent increase among children.
    Dengue hospitalisations in Brazil: annual wave from West to East and recent increase among children. [Journal Article]Epidemiol Infect 2017 Dec 13.:1-10.EIWunderlich J, Acuña-Soto R, Alonso WJ The number of dengue epidemics in Brazil has increased dramatically in the last 15 years. In this study, we analysed the seasonal patterns in the incidence of hospitalisations due to dengue across the ...Publisher Full TextThe number of dengue epidemics in Brazil has increased dramatically in the last 15 years. In this study, we analysed the seasonal patterns in the incidence of hospitalisations due to dengue across the different states of Brazil and compared these with the corresponding climatic patterns. We discovered that the seasonality of dengue hospitalisations in Brazil has a clear zonal gradient, characterised by the progression of primary peaks from West to East during the first half of the year, which may be associated with the increased vapour pressure and rainfall during this period, leading to increased mosquito abundance and activity. We also found that the proportion of children among hospitalised individuals was especially high during the peak outbreaks in 2007/2008 and 2010. This may be due to the emergence and spread of the new DENV-2 Southeast Asian genotype lineage II from 2007, which has probably arrived from the Caribbean and may have caused an increase in incidence and severity of the disease, particularly among children. Our findings may allow health systems to improve control interventions and contribute to reducing dengue morbidity and mortality by using integrated vector control in conjunction with early diagnosis and prompt supportive care.

  • Modulation of Lipid Droplet Metabolism-A Potential Target for Therapeutic Intervention in Flaviviridae Infections.
    Modulation of Lipid Droplet Metabolism-A Potential Target for Therapeutic Intervention in Flaviviridae Infections. [Journal Article, Review]Front Microbiol 2017.:2286.FMZhang J, Lan Y, Sanyal S Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage, lipid metabol...Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage, lipid metabolism and cellular homeostasis. It has become evident that viruses have co-evolved in order to exploit host lipid metabolic pathways. This is especially characteristic of the Flaviviridae family, including hepatitis C virus (HCV) and several flaviviruses. Devoid of an appropriate lipid biosynthetic machinery of their own, these single-strand positive-sense RNA viruses can induce dramatic changes in host metabolic pathways to establish a favorable environment for viral multiplication and acquire essential components to facilitate their assembly and traffic. Here we have reviewed the current knowledge on the intracellular life cycle of those from the Flaviviridae family, with particular emphasis on HCV and dengue virus (DENV), and their association with the biosynthesis and metabolism of LDs, with the aim to identify potential antiviral targets for development of novel therapeutic interventions.

  • Philippines halts dengue immunisation campaign owing to safety risk.
    Philippines halts dengue immunisation campaign owing to safety risk. [Journal Article]BMJ 2017 Dec 12.:j5759.BMJDyer O Publisher Full Text