Latest Articles on Dengue
- Assessment of community support for Wolbachia-mediated population suppression as a control method for Aedes aegypti mosquitoes in a community cohort in Puerto Rico Mon, 06 Dec 2021 06:00:00 -0500
Arboviral diseases transmitted by Aedes species mosquitoes pose an increasing public health challenge in tropical regions. Wolbachia-mediated population suppression (Wolbachia suppression) is a vector control method used to reduce Aedes mosquito populations by introducing male mosquitoes infected with Wolbachia, a naturally occurring endosymbiotic bacterium. When Wolbachia-infected male mosquitoes mate with female wild mosquitoes, the resulting eggs will not hatch. Public support is vital to the... - Effect of mutation of NS2B cofactor residues on Dengue 2 NS2B-NS3 protease complex - an insight to viral replication Mon, 06 Dec 2021 06:00:00 -0500
Dengue fever is an endemic virus-borne disease that causes many severe ailments, including dengue hemorrhagic fever and dengue shock syndrome. NS2B-NS3 protease is present in all four strains of the dengue virus. NS2B-NS3 is a non-structural protein that performs three distinct functions: protease activity, helicase activity, and nucleoside triphosphatase activity. NS2B-NS3 pro-complex plays a crucial role in viral replication, and NS2B interacts with NS3 protease at a flat active site with an... - N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity Mon, 06 Dec 2021 06:00:00 -0500
Most enveloped viruses rely on the host cell endoplasmic reticulum (ER) quality control (QC) machinery for proper folding of glycoproteins. The key ER α-glucosidases (α-Glu) I and II of the ERQC machinery are attractive targets for developing broad-spectrum antivirals. Iminosugars based on deoxynojirimycin have been extensively studied as ER α-glucosidase inhibitors; however, other glycomimetic compounds are less established. Accordingly, we synthesized a series of N-substituted derivatives of... - Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors Mon, 06 Dec 2021 06:00:00 -0500
Natural products constitute an important source of molecules for product development. However, despite numerous reports of compounds and active extracts from biodiversity, poor and developing countries continue to suffer with endemic diseases caused by arboviral vectors, including dengue, Zika, chikungunya and urban yellow fever. Vector control remains the most efficient disease prevention strategy. Wide and prolonged use of insecticides has resulted in vector resistance, making the search for... - Etiology and outcome of febrile children coming from the tropics Mon, 06 Dec 2021 06:00:00 -0500
CONCLUSION: Children with fever coming from tropical areas were at risk of severe infectious diseases. Malaria was diagnosed in one out of four and 7% required admission in PICU. This information emphasizes the need of reinforcing training about tropical diseases among first line physicians. - Dengue Virus Infection and Risk of Parkinson's Disease: A Nationwide Longitudinal Study Sun, 05 Dec 2021 06:00:00 -0500
No abstract - Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx Fri, 03 Dec 2021 06:00:00 -0500
Malaria caused by Plasmodium falciparum results in over 400,000 deaths annually, predominantly affecting African children. In addition, non-falciparum species including vivax and knowlesi cause significant morbidity and mortality. Vascular dysfunction is a key feature in malaria pathogenesis leading to impaired blood perfusion, vascular obstruction, and tissue hypoxia. Contributing factors include adhesion of infected RBC to endothelium, endothelial activation, and reduced nitric oxide... - Barriers and Proposed Solutions to a Successful Implementation of Pediatric Sepsis Protocols Fri, 03 Dec 2021 06:00:00 -0500
The implementation of managed protocols contributes to a systematized approach to the patient and continuous evaluation of results, focusing on improving clinical practice, early diagnosis, treatment, and outcomes. Advantages to the adoption of a pediatric sepsis recognition and treatment protocol include: a reduction in time to start fluid and antibiotic administration, decreased kidney dysfunction and organ dysfunction, reduction in length of stay, and even a decrease on mortality. Barriers... - Snake Bite and Dengue: A Twin Tragedy Fri, 03 Dec 2021 06:00:00 -0500
Dengue is a viral infection caused by the arboviridae family of viruses and is transmitted by the vector, a mosquito with the scientific name Aedes egyptii. The fever caused by the Dengue virus is best labelled as Break Bone fever because of the severe myalgia that accompanies the infection. Snakebite is also a global health problem. Mostly seen in tropical countries and countries with agriculture as the backbone of the economy, it has a varied presentation in such extremes that it can go from a... - An Outbreak of Arboviral Infection in a Region with Background Malaria Endemicity from Northwestern Nigeria: An Investigation Report Fri, 03 Dec 2021 06:00:00 -0500
CONCLUSIONS: The outbreak of febrile illness in Sokoto was linked to arboviral agents (Dengue virus and West Nile virus) in a malaria-endemic zone. We draw attention to the fact that arboviral infections can coexist with malaria in our region especially in an outbreak setting.