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Latest Articles on Dengue

  • Immunophenotyping and transcriptional profiling of human plasmablasts in dengue Wed, 15 Sep 2021 06:00:00 -0400
    Plasmablasts represent a specialized class of antibody secreting effector B cell population that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections leading to viral hemorrhagic fevers such as dengue or ebola. To gain a detailed understanding of the human plasmablast responses beyond antibody expression, here we performed immunophenotyping and RNA seq analysis of the...
  • Dengue and Coronavirus disease (COVID-19) syndemic: Double threat to an overburdened healthcare system in Africa Wed, 15 Sep 2021 06:00:00 -0400
    Dengue fever (DF) is a significant public health problem in the African continent. The primary prevention strategy against the disease is vaccination and entomological control of vectors; however, implementing such a strategy in several countries in the continent is far below what is necessary to control the disease. The Coronavirus disease (COVID-19) pandemic further aggravated this situation and negatively impacted these measures, mainly the coverage of vaccination campaigns, due to...
  • Dengue Myocarditis Complicated by COVID-19: A Case Report on Dual Viral Infection Wed, 15 Sep 2021 06:00:00 -0400
    During the ongoing pandemic of coronavirus disease 2019 (COVID-19), it is crucial for clinicians to have an insight into the emerging co-infections. As the dengue virus (DENV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have related symptomatology, a high index of suspicion is required for prompt diagnosis of concurrent infections involving these two pathogens, especially in the areas endemic for tropical diseases, i.e., dengue fever (DF), malaria, enteric fever,...
  • Splenic Infarction Induced by Dengue Hemorrhagic Fever: A Rare Presentation Wed, 15 Sep 2021 06:00:00 -0400
    Haematological and vascular features of dengue virus infection are common and vary from tiny skin haemorrhages to significant bleeding such as epistaxis, gastrointestinal bleeding and hematuria. Spontaneous splenic rupture has also been reported as an atypical manifestation in dengue fever. We report a case of splenic infarction in a 35-year-old man who presented with fever, vomiting, diffuse abdominal pain and distention, diarrhoea, hematuria, headache, back pain, hypotension, pleural effusion...
  • Third-generation smallpox vaccine strain-based recombinant vaccines for viral hemorrhagic fevers Wed, 15 Sep 2021 06:00:00 -0400
    Vaccinia virus has been used as a smallpox vaccine. Now that smallpox has been eradicated, the vaccinia virus is expected to be used as a bioterrorism countermeasure and a recombinant vaccine vector for other infectious diseases, such as viral hemorrhagic fevers. Many vaccinia virus strains were used as smallpox vaccines in the smallpox eradication campaign coordinated by the World Health Organization. These strains can be classified into generations, according to the history of improving...
  • Hyperendemicity associated with increased dengue burden Tue, 14 Sep 2021 06:00:00 -0400
    Over 105 million dengue infections are estimated to occur annually. Understanding the disease dynamics of dengue is often difficult due to multiple strains circulating within a population. Interactions between dengue serotype dynamics may result in complex cross-immunity dynamics at the population level and create difficulties in terms of formulating intervention strategies for the disease. In this study, a nationally representative 16-year time series with over 43 000 serotyped dengue...
  • Dengue virus in humans and mosquitoes and their molecular characteristics in northeastern Thailand 2016-2018 Tue, 14 Sep 2021 06:00:00 -0400
    Dengue is hyperendemic in most Southeast Asian countries including Thailand, where all four dengue virus serotypes (DENV-1 to -4) have circulated over different periods and regions. Despite dengue cases being annually reported in all regions of Thailand, there is limited data on the relationship of epidemic DENV infection between humans and mosquitoes, and about the dynamics of DENV during outbreaks in the northeastern region. The present study was conducted in this region to investigate the...
  • Identification of Phasi Charoen-Like Phasivirus in Field Collected Aedes aegypti from Karnataka State, India Tue, 14 Sep 2021 06:00:00 -0400
    Background: A wide range of insect-specific viruses (ISVs) have been reported worldwide. There are no studies from India that have reported ISVs. The current study describes the identification of Phasi Charoen-like virus (PCLV) from Aedes aegypti mosquito-pools from six districts of Karnataka state, India. Materials and Methods: During the Chikungunya virus (CHIKV) outbreak in the Bangalore Urban district in 2019, using conventional PCR, it was found that both human and mosquito samples were...
  • Clinicopathologic features between different viral epidemic outbreaks involving the skin Tue, 14 Sep 2021 06:00:00 -0400
    The current coronavirus disease 2019 pandemic has exceeded any epidemiologic prevision, but increasing information suggests some analogies with the major viral outbreaks of the last century. A general warning has been issued on the possibility that coinfections can make differential diagnosis and treatment difficult, especially in tropical countries. Some reports have pointed out that the presence of high Dengue antibodies can give a false-negative result for severe acute respiratory syndrome...
  • Seroprevalence of Zika virus in pregnant women from central Thailand Mon, 13 Sep 2021 06:00:00 -0400
    Zika virus (ZKV) infection in a pregnant woman, especially during the first trimester, often results in congenital anomalies. However, the pathogenic mechanism is unknown and one-third of ZKV infected pregnancies are asymptomatic. Neutralizing antibodies against ZKV has been reported in 70% of Thai adults, but the prevalence among pregnant women is unknown. Currently, vaccines and specific treatments for ZKV are under development. A better understanding of the immune status of pregnant women...