Latest Articles on Dengue
- Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques Fri, 30 Jul 2021 06:00:00 -0400
Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal... - Phenotypical characterization of regulatory T cells in acute Zika infection Thu, 29 Jul 2021 06:00:00 -0400
Zika virus (ZIKV), alongside Dengue virus (DENV), Chikungunya virus (CHIKV), and Yellow Fever Virus (YFV) are prevalent arboviruses in the Americas. Each of these infections is associated with the development of associated disease immunopathology. Immunopathological processes are an outcome of counter-balancing impacts between effector and regulatory immune mechanisms. In this context, regulatory T cells (Tregs) are key in modulating the immune response and, therefore, in tissue damage control.... - Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis Thu, 29 Jul 2021 06:00:00 -0400
Delayed plasma leakage recognition could lead to improper fluid administration resulting in dengue shock syndrome, subsequently, multi-organ failure, and death. This prospective observational study was conducted in Bangkok, Thailand, between March 2018 and February 2020 to determine predictors of plasma leakage and develop a plasma leakage predictive score among dengue patients aged ≥15 years. Of 667 confirmed dengue patients, 318 (47.7%) developed plasma leakage, and 349 (52.3%) had no plasma... - Target product profile for a dengue pre-vaccination screening test Thu, 29 Jul 2021 06:00:00 -0400
With increasing geographic spread, frequency, and magnitude of outbreaks, dengue continues to pose a major public health threat worldwide. Dengvaxia, a dengue live-attenuated tetravalent vaccine, was licensed in 2015, but post hoc analyses of long-term data showed serostatus-dependent vaccine performance with an excess risk of hospitalized and severe dengue in seronegative vaccine recipients. The World Health Organization (WHO) recommended that only persons with evidence of past dengue infection... - Reducing mosquito-borne disease transmission to humans: A systematic review of cluster randomised controlled studies that assess interventions other than non-targeted insecticide Thu, 29 Jul 2021 06:00:00 -0400
CONCLUSION: High community engagement is vital for a cRCT reducing mosquito-borne disease with a mosquito control intervention. These findings support a mosquito breeding source reduction intervention for Aedes control in a future study of Buruli ulcer prevention if local communities are supportive and very engaged. Regular administration of larvicide to sites unsuited to source reduction may supplement the intervention. - Arboviral Diseases and COVID-19 Coincidence: Challenges for Pakistan's Derelict Healthcare System Thu, 29 Jul 2021 06:00:00 -0400
No abstract - Paradigm Shift in Socio-Demographic Profile of Dengue Infection: A Hospital Based Cross-Sectional Study Thu, 29 Jul 2021 06:00:00 -0400
CONCLUSION: The study highlights the need to curb the rural spread of the disease through activities in creating awareness among all section of people to promote control measures and early reporting of all fever cases, capacity building of rural doctors for early detection, treatment and early referral of high-risk patients and availability of ELISA based tests in sub-district hospitals along with Rapid Diagnostic Kits (RDKs). Emphasis for preventive and control measures to be increased during... - Efficacy of Tetravalent Dengue Vaccine: A Systematic Review and Meta-Analysis Thu, 29 Jul 2021 06:00:00 -0400
Dengue is one of the neglected tropical diseases caused by flavivirus. Live-attenuated tetravalent vaccine is launched for the age group of 9-45 years. It is given in three doses schedule. Eleven studies were included in meta-analysis by following PRISMA guidelines. Healthy persons in the age group of 2-45 years were included in these studies. Statistical analysis was done by "R" software. Pooled relative risk among vaccinated versus control group was calculated using random-effect model. Pooled... - Performance assessment of a multi-epitope chimeric antigen for the serological diagnosis of acute Mayaro fever Thu, 29 Jul 2021 06:00:00 -0400
Mayaro virus (MAYV), which causes mayaro fever, is endemic to limited regions of South America that may expand due to the possible involvement of Aedes spp. mosquitoes in its transmission. Its effective control will require the accurate identification of infected individuals, which has been restricted to nucleic acid-based tests due to similarities with other emerging members of the Alphavirus genus of the Togaviridae family; both in structure and clinical symptoms. Serological tests have a more... - Early Predictors of Mortality in Children with Severe Dengue Fever: A Prospective Study Thu, 29 Jul 2021 06:00:00 -0400
CONCLUSION: Disease severity, hyperlactatemia at admission, need for multiple vasoactive drugs and positive fluid balance are predictors of mortality in severe dengue infection in children admitted to PICU.