Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Double blow: Bangladesh battles dengue outbreak amid COVID crisis - Al Jazeera English
  Fri, 30 Jul 2021 09:33 GMT
• Global warming may limit spread of dengue fever, new research finds | Penn State University - Penn State News
  Thu, 22 Jul 2021 07:00 GMT
• Higher temperatures could limit the spread of dengue infection - News-Medical.Net
  Wed, 28 Jul 2021 00:46 GMT
• Lost in post-translational modification—Dengue virus writes its own sequel - Science
  Fri, 02 Jul 2021 07:00 GMT
• Deploying Specialized Mosquitos Successfully Curbs Dengue Incidence - Contagionlive.com
  Fri, 09 Jul 2021 07:00 GMT
• Philippines dengue: Pangasinan reports doubling of cases in 2021 - Outbreak News Today - Outbreak News Today
  Sat, 31 Jul 2021 11:37 GMT
• Mapping dengue hot spots pinpoints risks for Zika and chikungunya - Emory News Center
  Wed, 07 Jul 2021 07:00 GMT
• Central America: Dengue Outbreak - Emergency Appeal Final Report (MDR42005) - Honduras - ReliefWeb
  Mon, 26 Jul 2021 20:48 GMT
• Mapping dengue fever hot spots can predict future outbreaks of Zika and chikungunya - News-Medical.Net
  Wed, 07 Jul 2021 07:00 GMT
• 196 more dengue patients hospitalized in 24 hours - Dhaka Tribune
  Sat, 31 Jul 2021 14:55 GMT
• Climate crisis ‘may put 8bn at risk of malaria and dengue’ - The Guardian
  Thu, 08 Jul 2021 07:00 GMT
• Bangladesh reports surge of dengue fever in July, Most in Dhaka - Outbreak News Today - Outbreak News Today
  Tue, 27 Jul 2021 22:52 GMT
• Dengue cases rising in Dhaka: Key terminals, depots turn Aedes hotspots - The Daily Star
  Fri, 30 Jul 2021 18:00 GMT
• Looking out for dengue this monsoon: Know the symptoms and methods of prevention - Times Now
  Mon, 19 Jul 2021 07:00 GMT
• Virulent D2 strain found as Bhubaneswar sees dengue surge - The New Indian Express
  Thu, 29 Jul 2021 03:18 GMT

• PRO/AH/EDR> Leptospirosis - Guyana: (EB) flooding
  Sun, 18 Jul 2021 15:52:28 -0400
  Leptospirosis -- Guyana
  Following major flooding in the country, Region 6 is reporting 67 cases of dengue and 5 cases of leptospirosis.
  Regional Chairman, David Armogan, during a press briefing in Region 6 yesterday, relayed that that while there are 67 cases of the mosquito-borne dengue presently there has not been any major escalation since.
  "A number of areas are pretty dry, Black Bush Polder they don't have much difficulties with flooding and so, and a lot of those cases came out from Black Bush too", he

• Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques Fri, 30 Jul 2021 06:00:00 -0400
  Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal...
• Phenotypical characterization of regulatory T cells in acute Zika infection Thu, 29 Jul 2021 06:00:00 -0400
  Zika virus (ZIKV), alongside Dengue virus (DENV), Chikungunya virus (CHIKV), and Yellow Fever Virus (YFV) are prevalent arboviruses in the Americas. Each of these infections is associated with the development of associated disease immunopathology. Immunopathological processes are an outcome of counter-balancing impacts between effector and regulatory immune mechanisms. In this context, regulatory T cells (Tregs) are key in modulating the immune response and, therefore, in tissue damage control....
• Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis Thu, 29 Jul 2021 06:00:00 -0400
  Delayed plasma leakage recognition could lead to improper fluid administration resulting in dengue shock syndrome, subsequently, multi-organ failure, and death. This prospective observational study was conducted in Bangkok, Thailand, between March 2018 and February 2020 to determine predictors of plasma leakage and develop a plasma leakage predictive score among dengue patients aged ≥15 years. Of 667 confirmed dengue patients, 318 (47.7%) developed plasma leakage, and 349 (52.3%) had no plasma...
• Target product profile for a dengue pre-vaccination screening test Thu, 29 Jul 2021 06:00:00 -0400
  With increasing geographic spread, frequency, and magnitude of outbreaks, dengue continues to pose a major public health threat worldwide. Dengvaxia, a dengue live-attenuated tetravalent vaccine, was licensed in 2015, but post hoc analyses of long-term data showed serostatus-dependent vaccine performance with an excess risk of hospitalized and severe dengue in seronegative vaccine recipients. The World Health Organization (WHO) recommended that only persons with evidence of past dengue infection...
• Reducing mosquito-borne disease transmission to humans: A systematic review of cluster randomised controlled studies that assess interventions other than non-targeted insecticide Thu, 29 Jul 2021 06:00:00 -0400
  CONCLUSION: High community engagement is vital for a cRCT reducing mosquito-borne disease with a mosquito control intervention. These findings support a mosquito breeding source reduction intervention for Aedes control in a future study of Buruli ulcer prevention if local communities are supportive and very engaged. Regular administration of larvicide to sites unsuited to source reduction may supplement the intervention.
• Arboviral Diseases and COVID-19 Coincidence: Challenges for Pakistan's Derelict Healthcare System Thu, 29 Jul 2021 06:00:00 -0400
  No abstract
• Paradigm Shift in Socio-Demographic Profile of Dengue Infection: A Hospital Based Cross-Sectional Study Thu, 29 Jul 2021 06:00:00 -0400
  CONCLUSION: The study highlights the need to curb the rural spread of the disease through activities in creating awareness among all section of people to promote control measures and early reporting of all fever cases, capacity building of rural doctors for early detection, treatment and early referral of high-risk patients and availability of ELISA based tests in sub-district hospitals along with Rapid Diagnostic Kits (RDKs). Emphasis for preventive and control measures to be increased during...
• Efficacy of Tetravalent Dengue Vaccine: A Systematic Review and Meta-Analysis Thu, 29 Jul 2021 06:00:00 -0400
  Dengue is one of the neglected tropical diseases caused by flavivirus. Live-attenuated tetravalent vaccine is launched for the age group of 9-45 years. It is given in three doses schedule. Eleven studies were included in meta-analysis by following PRISMA guidelines. Healthy persons in the age group of 2-45 years were included in these studies. Statistical analysis was done by "R" software. Pooled relative risk among vaccinated versus control group was calculated using random-effect model. Pooled...
• Performance assessment of a multi-epitope chimeric antigen for the serological diagnosis of acute Mayaro fever Thu, 29 Jul 2021 06:00:00 -0400
  Mayaro virus (MAYV), which causes mayaro fever, is endemic to limited regions of South America that may expand due to the possible involvement of Aedes spp. mosquitoes in its transmission. Its effective control will require the accurate identification of infected individuals, which has been restricted to nucleic acid-based tests due to similarities with other emerging members of the Alphavirus genus of the Togaviridae family; both in structure and clinical symptoms. Serological tests have a more...
• Early Predictors of Mortality in Children with Severe Dengue Fever: A Prospective Study Thu, 29 Jul 2021 06:00:00 -0400
  CONCLUSION: Disease severity, hyperlactatemia at admission, need for multiple vasoactive drugs and positive fluid balance are predictors of mortality in severe dengue infection in children admitted to PICU.