Dengue Virus Net is the web resource for anyone interested in dengue. Dengue is a mosquito-borne infection that causes a severe flu-like illness (dengue fever), and sometimes a potentially lethal complication called dengue haemorrhagic fever. Global incidence of dengue has grown dramatically in recent decades. About two fifths of the world's population are now at risk. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day. Dengue haemorrhagic fever is a leading cause of serious illness and death among children in some Asian countries. A vaccine for dengue fever has been approved by the FDA in May 2019 and is commercially available in a number of countries.

The objectives of Dengue Virus Net are to be the public and professional information resource for dengue and to serve as a network in the exchange of information and news related to dengue.

• Highly potent antiviral against dengue could prevent spread of virus - Drug Target Review
  Tue, 19 Oct 2021 09:02 GMT
• Antibodies produced during dengue lead to massive destruction of platelets: Doctor - The Indian Express
  Tue, 19 Oct 2021 02:22 GMT
• 1st dengue death in Delhi this year as cases spike - Hindustan Times
  Mon, 18 Oct 2021 20:07 GMT
• Potent Dengue Antiviral Effective against All Known Variants - Genetic Engineering & Biotechnology News
  Thu, 07 Oct 2021 07:00 GMT
• Scientists at CDRI Lucknow develop anti-viral drug to treat dengue: All you need to know - Hindustan Times
  Wed, 20 Oct 2021 02:31 GMT
• Island Pharmaceuticals to discuss its potential dengue fever preventative at Pharma Meeting Brazil & Latam 2021 - PRNewswire
  Wed, 20 Oct 2021 10:00 GMT
• Residents warned against losing focus on dengue fever - Antigua Observer
  Wed, 29 Sep 2021 07:00 GMT
• 'An amazing ride': study offers dengue treatment hope - Medical Xpress
  Wed, 06 Oct 2021 07:00 GMT
• 480 cases and counting: Dengue uptick stings Delhi - The Indian Express
  Sun, 17 Oct 2021 23:07 GMT
• Dengue compound backed by J&J shows potency against the virus and all known variants in mice - FierceBiotech
  Wed, 06 Oct 2021 07:00 GMT
• MCG kicks off fogging drive as dengue cases rise - Hindustan Times
  Wed, 20 Oct 2021 17:37 GMT
• Dengue claims two more lives in Mohali district, toll 14 - The Tribune India
  Wed, 20 Oct 2021 05:06 GMT
• Dengue death toll reaches five, KP reports 79 fresh cases - SUCH TV
  Wed, 20 Oct 2021 04:09 GMT
• Punjab: Prolonged monsoon may push up dengue cases till November end, say experts - India Today
  Wed, 20 Oct 2021 18:52 GMT
• DENV2 Explained: What You Should Know About Dangerous Dengue Strain - NDTV
  Tue, 28 Sep 2021 07:00 GMT

• PRO/AH/EDR> Invasive mosquito - France (03): (BT)
  Mon, 06 Sep 2021 21:28:53 -0400
  Yellow Fever, Zika virus, Dengue, Chikungunya -- France
  A potentially deadly mosquito that can carry viruses such as yellow fever and Zika has been spotted in Brittany, northern France, sparking fears they may soon land on British shores. Asian tiger mosquitoes [_Aedes albopictus_] have been confirmed to be in the commune of Domagne in the department of Ile-et-Vilaine in western Brittany.
  Health authorities are preparing an intensive campaign to rid the area of the insects with strong insecticides.
  The creatures were 1st seen in France in the

• High seroprevalence of anti-DENV IgM in blood donors in an early outbreak in the Federal District of Brazil, 2019 Wed, 20 Oct 2021 06:00:00 -0400
  Dengue is endemic in Brazil, and several Brazilian cities are affected by frequent seasonal outbreaks of the disease. During the outbreaks the possibility of transfusion-transmitted dengue (TTD) is increased, mainly by the presence of asymptomatic or oligosymptomatic infections in eligible blood donors. The retrospective assessment of anti-DENV IgM and NS1 seroprevalence during a given time interval may indicate the need for measures for the previous screening of DENV infection in blood donors....
• Regarding the article "Aedes aegypti, the dengue fever mosquito in Mexico City. Early invasion and its potential risks" Wed, 20 Oct 2021 06:00:00 -0400
  No abstract
• Global dengue importation: a systematic review Wed, 20 Oct 2021 06:00:00 -0400
  CONCLUSION: The potential of dengue outbreaks occurring globally, especially among non-endemic regions with dengue-susceptible populations is high. With the expansion of Aedes mosquito population globally due to global warming and globalisation, dengue importation constitutes an emerging global health security threat.
• Viperin is anti-viral in vitro but is dispensable for restricting dengue virus replication or induction of innate and inflammatory responses in vivo Tue, 19 Oct 2021 06:00:00 -0400
  Viperin has antiviral function against many viruses, including dengue virus (DENV), when studied in cells in culture. Here, the antiviral actions of viperin were defined both in vitro and in a mouse in vivo model of DENV infection. Murine embryonic fibroblasts (MEFs) derived from mice lacking viperin (vip^(-/-)) showed enhanced DENV infection, accompanied by increased IFN-β and induction of ISGs; IFIT1 and CXCL-10 but not IRF7, when compared to wild-type (WT) MEFs. In contrast, subcutaneous...
• Detection of Saint Louis Encephalitis virus in two Brazilian States Tue, 19 Oct 2021 06:00:00 -0400
  We describe the circulation of Saint Louis encephalitis virus (SLEV) in two Brazilian States during outbreaks of Dengue and Zika viruses. We detected the virus in patients from Araraquara, State of São Paulo, and in patients and mosquitoes Culex quinquefasciatus from Sinop, State of Mato Grosso. Phylogenetic analysis grouped our samples within genotype V, which are closely related to other strains. This genotype was previously detected in other parts of the country and seems to have established...
• Climate change and infectious disease in Europe: Impact, projection and adaptation Tue, 19 Oct 2021 06:00:00 -0400
  Europeans are not only exposed to direct effects from climate change, but also vulnerable to indirect effects from infectious disease, many of which are climate sensitive, which is of concern because of their epidemic potential. Climatic conditions have facilitated vector-borne disease outbreaks like chikungunya, dengue, and West Nile fever and have contributed to a geographic range expansion of tick vectors that transmit Lyme disease and tick-borne encephalitis. Extreme precipitation events...
• Timely surveillance and temporal calibration of disease response against human infectious diseases Mon, 18 Oct 2021 06:00:00 -0400
  CONCLUSION: We identify practically achievable, timely surveillance thresholds (on temporal scale) that lead to an effective response and identify how they can be satisfied. Our approach can be utilized to provide guidelines on spatially and demographically targeted resource allocation for public awareness campaigns as well as to improve diagnostic abilities and turn-around times for the doctors and laboratories involved.
• Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti Mon, 18 Oct 2021 06:00:00 -0400
  CONCLUSION: Results from this study show that bioallethrin repellency is likely the result of co-activation of Or(s) and sodium channels. These findings not only contribute to the understanding of the modes of action of volatile pyrethroids in spatial repellency, but also provide a framework for developing new repellents based on the dual-target mechanism revealed. This article is protected by copyright. All rights reserved.
• Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A Mon, 18 Oct 2021 06:00:00 -0400
  While a drug treatment is unavailable, the global incidence of Dengue virus (DENV) infections and its associated severe manifestations continues to rise. We report the construction of the first physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model that predicts viremia levels in relevant target organs based on preclinical data with the broad spectrum antiviral soraphen A (SorA), an inhibitor of the host cell target acetyl-CoA-carboxylase. SorA was highly effective against DENV in...
• Viral characteristics and clinical presentation in dengue co-infection- Findings from a facility based observational study in Odisha, India Mon, 18 Oct 2021 06:00:00 -0400
  CONCLUSIONS: All the four dengue serotypes were found to be circulating with DEN 2 as the most predominant one. About 5.8% of dengue cases have co-infection (mainly with Chikungunya) and clinically present with atypical signs and symptoms.